7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉

生物活性靶點(diǎn)體外研究 用途與合成方法 MSDS 7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉價格(試劑級) 上下游產(chǎn)品信息

中文名稱	7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉
中文同義詞	7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉;雙位點(diǎn)SRC酪氨酸激酶抑制劑(SRC INHIBITOR 1);6,7-二甲氧基-N-(4-苯氧基苯基)-4-喹唑啉胺;SRC抑制劑1;化合物SRC INHIBITOR 1;6,7-二甲氧基-N-(4-苯氧基苯基)喹唑啉-4-胺;6,7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉
英文名稱	6,7-Dimethoxy-N-(4-phenoxyphenyl)-
英文同義詞	6,7-Dimethoxy-N-(4-phenoxyphenyl)-;Src I1;SKI-1;Src Inhibitor-1;Src-l1;ANTI-HHAT (N-TERM) antibody produced in rabbit;HHAT;MART2
CAS號	179248-59-0
分子式	C22H19N3O3
分子量	373.4
EINECS號
相關(guān)類別	細(xì)胞生物學(xué)試劑;合成;標(biāo)準(zhǔn)品;Amines;Aromatics;Heterocycles;Inhibitors
Mol文件	179248-59-0.mol
結(jié)構(gòu)式

7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉 性質(zhì)

7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉 用途與合成方法

生物活性

Src Inhibitor 1是Src和Lck的競爭性抑制劑，IC50分別為44 nM和88 nM。它也能抑制Csk和Yes。

靶點(diǎn)

體外研究

Src-I1 is competitive with both ATP and peptide binding sites of the kinase. The IC     ₅₀    values are 44 and 88 nM for Src and Lck, respectively. Src-I1, is found to be a potent inhibitor of Src (IC     ₅₀    =0.18 μM), but also inhibited other Src family members, such as Lck, Csk and Yes with similar potency to Src, and RIP2 (IC     ₅₀    =0.026 μM) with even greater potency. In addition, it inhibited CHK2 with similar potency to Src, and Aurora B with slightly lower potency.

安全信息

MSDS信息

7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉 價格(試劑級)

7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉 上下游產(chǎn)品信息