L-抗壞血酸-2-單磷酸酯三環(huán)己銨鹽

生物活性靶點(diǎn)體外研究

中文名稱	L-抗壞血酸-2-單磷酸酯三環(huán)己銨鹽
中文同義詞	維生素C磷酸酯(L-抗壞血酸-2-磷酸酯);L-抗壞血酸-2-單磷酸酯三環(huán)己銨鹽;化合物 T19390;2-磷酸抗壞血酸;維生素C磷酸酯35%;抗壞血酸2-磷酸鹽
英文名稱	L-ASCORBIC ACID 2-MONOPHOSPHATE TRI-CYCLOHEXYLAMMONIUM SALT
英文同義詞	Vitamin C phosphate;l-ascorbic acid 2-monophosphate tris-cyclohexylammonium salt;[2-(1,2-dihydroxyethyl)-3-hydroxy-5-oxo-2H-furan-4-yl] dihydrogen phosphate;Ascorbic Acid Impurity 6;ascorbate-2-phosphate;Ascorbyl monophosphate;Ascorbyl-2-monophosphate;Ascorbyl-2-phosphate
CAS號	23313-12-4
分子式	C6H9O9P
分子量	256.1
EINECS號	601-297-5
相關(guān)類別	中間體;有機(jī)化工原料;食品添加劑;維生素C 系列
Mol文件	23313-12-4.mol
結(jié)構(gòu)式

L-抗壞血酸-2-單磷酸酯三環(huán)己銨鹽 性質(zhì)

L-抗壞血酸-2-單磷酸酯三環(huán)己銨鹽 用途與合成方法

生物活性

L-ascorbic acid 2-phosphate 是一種長效的維生素 C 衍生物 (vitamin C derivative)，可以刺激膠原蛋白的表達(dá)和形成。L-ascorbic acid 2-phosphate 可以作為培養(yǎng)基補(bǔ)充人脂肪干細(xì)胞 (hASCs) 的成骨分化。L-ascorbic acid 2-phosphate 增加成骨細(xì)胞分化過程中 hASC 中的堿性磷酸酶 (ALP) 活性和 runx2A 的表達(dá)。

靶點(diǎn)

IC50: alkaline phosphatase (ALP); collagen formation; runx2A

體外研究

L-Ascorbic acid 2-phosphate (0.1-1.5 mM; 2 to 3 weeks with medium exchange every 2 to 3 days) significantly stimulates cell growth, whereas addition of l-Ascorbic acid (Asc)  achieves only weak growth stimulation. A combination of Asc-2P and bFGF significantly increases cell growth, but supplementation with EGF and/or insulin does not have any additional effect .L-Ascorbic acid 2-phosphate (50 μM-250 μM) is needed for the effective osteogenic differentiation of human adipose stem cells (hASCs), and higher concentrations of AsA2-P results in increased runx2 expression and ALP activity. The highest proliferation, ALP activity and runx2 expression is achieved with 150 μM AsA2-P and 10 nM dexamethasone (Dex), and 250 μM AsA2-P and 5 nM Dex.

Cell Proliferation Assay

安全信息

MSDS信息

L-抗壞血酸-2-單磷酸酯三環(huán)己銨鹽 上下游產(chǎn)品信息