食欲肽B (人)

生物活性靶點(diǎn)體外研究體內(nèi)研究

中文名稱(chēng)	食欲肽B (人)
中文同義詞	食欲肽B(人) ≥98%;食欲肽B(人) ≥98%, ≥98% (HPLC);人OREXIN B;食欲肽B (人);RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2 (TRIFLUOROACETATE SALT);食欲素B(人類(lèi))三氟乙酸鹽;化合物 OREXIN B, HUMAN
英文名稱(chēng)	OREXIN B (HUMAN)
英文同義詞	REF DUPL: Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2;Orexin B (huMan) Hypocretin-2 (huMan);OREXIN B HUMAN ≥98%;Orexin B (human), ≥98% (HPLC);PubChem ID: 90479794;ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2;HYPOCRETIN-2;HYPOCRETIN-2, HUMAN
CAS號(hào)	205640-91-1
分子式	C123H212N44O35S
分子量	2899.34
EINECS號(hào)
相關(guān)類(lèi)別	其他生化試劑;生化試劑;多肽;標(biāo)準(zhǔn)品;proteins;Peptide;Orexin receptor
Mol文件	205640-91-1.mol
結(jié)構(gòu)式

食欲肽B (人) 性質(zhì)

食欲肽B (人) 用途與合成方法

生物活性

Orexin B, human是 Orexin 受體的內(nèi)源性激動(dòng)劑，與OX1和OX2結(jié)合的 Ki 值分別為 420 和 36 nM。

靶點(diǎn)

Ki: 420 nM (OX1), 36 nM (OX2)

體外研究

Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor. Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC     ₅₀    of 36 nM in the binding assay and an EC     ₅₀    of 60 nM in the [Ca     ²⁺    ]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC     ₅₀    in the competitive binding assay and the EC     ₅₀    in the [Ca     ²⁺    ]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively.

體內(nèi)研究

Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively.

參考質(zhì)量標(biāo)準(zhǔn)

外觀:白色粉末
純度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
內(nèi)毒素≤50EU/mg
氨基酸組成分析≤±10%

安全信息

MSDS信息

食欲肽B (人) 上下游產(chǎn)品信息