異土木香內(nèi)酯

生物活性靶點體外研究體內(nèi)研究 用途與合成方法 MSDS 異土木香內(nèi)酯價格(試劑級) 上下游產(chǎn)品信息

中文名稱	異土木香內(nèi)酯
中文同義詞	異土木香內(nèi)酯(異阿蘭內(nèi)酯);異土木香內(nèi)酯, 來源于土木香;ISOALANTOLACTONE 異土木香內(nèi)酯 標(biāo)準(zhǔn)品;異土木香內(nèi)酯;異阿蘭內(nèi)酯;異土木香內(nèi)酯(標(biāo)準(zhǔn)品);異木香內(nèi)脂;ISOALANTOLACTONE 異土木香內(nèi)酯
英文名稱	Isoalantolactone
英文同義詞	11(13)-dien-12-oicacid,8-beta-hydroxy-eudesma-4(14gamma-lactone;ISOALANTOACTONE;ISOALANTOLACTONE;ISOHELENIN;(3ar,4as,8ar,9ar)-8a-methyl-3,5-dimethylene-decahydro-naphtho[2,3-b]furan-2-one;methyl-3,5-bis(methylene)-,(3aR,4aS,8aR,9aR)-;Naphtho[2,3-b]furan-2(3H)-one,decahydro-8a-;(3aR)-3aα,4,4aα,5,6,7,8,8a,9,9aα-Decahydro-3,5-bismethylene-8aβ-methylnaphtho[2,3-b]furan-2(3H)-one
CAS號	470-17-7
分子式	C15H20O2
分子量	232.32
EINECS號
相關(guān)類別	分析對照品;標(biāo)準(zhǔn)品-對照品;分析試劑標(biāo)準(zhǔn)品;中藥對照品;標(biāo)準(zhǔn)品;植物提取物;對照品;植提標(biāo)準(zhǔn)品;小分子抑制劑;小分子抑制劑，天然產(chǎn)物;標(biāo)準(zhǔn)品-中藥標(biāo)準(zhǔn)品;標(biāo)準(zhǔn)品 -中藥標(biāo)準(zhǔn)品;Miscellaneous Natural Products;chiral;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;倍半萜;標(biāo)準(zhǔn)品，對照品;有機化工原料;倍半萜內(nèi)酯
Mol文件	470-17-7.mol
結(jié)構(gòu)式

異土木香內(nèi)酯 性質(zhì)

異土木香內(nèi)酯 用途與合成方法

生物活性

異土木香內(nèi)酯是一種烷化劑，用作細胞凋亡 (apoptosis) 誘導(dǎo)劑。

靶點

體外研究

Isoalantolactone exhibits good cytotoxic activity against the K562 human leukaemia cell line (IC     ₅₀    =1.2 μM) . The cytotoxic effect of Isoalantolactone on pancreatic carcinoma is evaluated using PANC-1, BxPC3 and HPAC cell lines. Treatment with Isoalantolactone for 24 h inhibits PANC-1 cell growth in a dose-dependent manner. The inhibition rate is above 90% at 80 μM and the concentration to achieve 50% growth inhibition (IC     ₅₀    ) is 40 μM. A similar trend in loss of cell viability is observed in BxPC3 and HPAC cells on Isoalantolactone treatment with IC     ₅₀    values 43 and 48 μM respectively. Pretreatment with 3 mM N-Acetyl Cysteine (NAC), a specific ROS scavenger, restores the viability of cells indicating that Isoalantolactone exerts cytotoxic effect on cell viability through ROS generation.

體內(nèi)研究

The acute and chronic toxic effects of Isoalantolactone in CD1 mice are assessed by measuring the changes in body weight, blood biochemistry and histopathology of liver and kidneys in comparison with control groups. Isoalantolactone is well tolerated by mice and no mortality or any sign of pharmacotoxicity are found at a dose of 100 mg/kg during both experimental periods (7 & 30 days). Body weight gains and food consumption are comparable for control and treated mice during both experimental periods and there were no drug-related changes in histopathological and blood biochemistry parameters. The histopathological changes in liver and kidneys are assessed using hematoxylin and eosin staining and correlated with liver and renal function biomarkers. No obvious morphological changes are observed in liver and kidney structures of control and treatment groups. There is a slight increase in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) level of treatment group at dose day 7 but this increase is not significantly different (P<0.05) from control group. A significant increase in total bilirubin (TBIL) concentration is found in treatment group (1.43±0.26 vs 0.76±0.12 in control, P<0.05) at dose day 7. Similarly the changes in renal function biomarkers are not significantly different (P<0.05) in the serum of control and treatment groups at dose day 7. The concentration of creatinine (Cr) slightly increases whereas concentration of blood urea nitrogen (BUN) slightly decreases in treatment group. The serum level of AST, ALT, TBIL and BUN slightly decreases when mice are injected with Isoalantolactone at a dose of 100 mg/kg for 30 days.

化學(xué)性質(zhì) 

白色粒狀結(jié)晶，溶于乙醇、乙醚、苯和氯仿，微溶于石油醚不溶于水，來源于藏木香,土木香，大葉土木香 Inula grandis，加拿大蒼耳 Xanthium canadense，木香 Saussurea lappa [Svn．Aucklandia lappa]，土木香 lnula helenium，喜馬旋覆花 Inula royleana，總狀土木香 lnula racemosa。

用途 

異土木香內(nèi)酯具有驅(qū)蟲、抗菌的作用。

安全信息

MSDS信息

異土木香內(nèi)酯 價格(試劑級)

異土木香內(nèi)酯 上下游產(chǎn)品信息

上游原料