鹽酸苯氟雷司

生物活性靶點體外研究 用途與合成方法 MSDS 鹽酸苯氟雷司價格(試劑級) 上下游產(chǎn)品信息

中文名稱	鹽酸苯氟雷司
中文同義詞	鹽酸苯氟雷司;N-(1-甲基-2-(3-[三氟甲基]-苯基)乙基]氨基乙醇苯甲酸酯;2-((1-(3-(三氟甲基)苯基)丙烷-2-基)氨基)乙基苯酸鹽鹽酸
英文名稱	BENFLUOREX HYDROCHLORIDE
英文同義詞	2-((1-methyl-2-(3-(trifluoromethyl)phenyl)ethyl)amino)-ethanobenzoate(est;2-((alpha-methyl-m-(trifluoromethyl)phenethyl)amino)-ethanobenzoate(est;2-((1-(3-(trifluoromethyl)phenyl)propan-2-yl)amino)ethyl benzoate hydrochloride;mediator;BENFLUOREX HYDROCHLORIDE;2-[[1-METHYL-2-[3-(TRIFLUOROMETHYL)-PHENYL]ETHYL]AMINO]ETHANOL BENZOATE (ESTER) HCL;2-[[1-METHYL-2[3-(TRIFLUOROMETHYL)-PHENYL]ETHYL]AMINO]ETHANOL BENZOATE ESTER HYDROCHLORIDE;2-((1-METHYL-2-[3-(TRIFLUOROMETHYL)PHENYL]ETHYL)AMINO)ETHYL BENZOATE HYDROCHLORIDE
CAS號	23642-66-2
分子式	C19H20F3NO2.ClH
分子量	387.82
EINECS號	245-801-8
相關(guān)類別	小分子抑制劑;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol文件	23642-66-2.mol
結(jié)構(gòu)式

鹽酸苯氟雷司 性質(zhì)

鹽酸苯氟雷司 用途與合成方法

生物活性

Benfluorex hydrochloride (JP-992 hydrochloride) 是一個肝核因子 4α (HNF4α) 激活劑。

靶點

HNF4α

體外研究

Benfluorex hydrochloride consistently activates insulin promoter activity as measured by an increased number of GFP-positive cells. Benfluorex hydrochloride increases the number of GFP-positive cells in a dose-responsive manner and increases the level of endogenous insulin mRNA. Consistent with being HNF4α activator, Benfluorex hydrochloride stimulates HNF4α expression. Benfluorex hydrochloride alters HNF4α protease sensitivity, while the inactive control compound does not. Benfluorex hydrochloride decreases, in a concentration-dependent manner, the synthesis of acid-soluble products and ketone bodies from oleate, whereas the production of     ¹⁴    CO     ₂    into citric acid cycle is markedly increased by Benfluorex hydrochloride. Benfluorex hydrochloride inhibits in a dose-dependent manner the rates of gluconeogenesis from lactate/pyruvate (10/1 nM).

安全信息

MSDS信息

鹽酸苯氟雷司 價格(試劑級)

鹽酸苯氟雷司 上下游產(chǎn)品信息

上游原料

苯甲酰氯