CPD1578

生物活性靶點體外研究 用途與合成方法 MSDS CPD1578價格(試劑級) 上下游產(chǎn)品信息

中文名稱	CPD1578
中文同義詞	7-(間甲苯基)吡唑并[1,5-A]嘧啶-3-甲酰胺;化合物CU-CPT-8M
英文名稱	CU-CPT-8m
英文同義詞	CPD1578;CU-CPT-8m;cas 125079-83-6;CU-CPT-8M;CAS 125079-83-6 ;TLR8 INHIBITOR;TLR8-specific antagonist;7-(m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 7-(3-methylphenyl)-;CU CPT 8m,inhibit,Toll-like Receptor (TLR),CUCPT8m,Inhibitor
CAS號	125079-83-6
分子式	C14H12N4O
分子量	252.27
EINECS號
相關(guān)類別
Mol文件	125079-83-6.mol
結(jié)構(gòu)式

CPD1578 性質(zhì)

CPD1578 用途與合成方法

生物活性

CU-CPT-8m 是 TLR8 的特異性拮抗劑，其 IC50 值為 67 nM。

靶點

體外研究

CU-CPT-8m is a specific     TLR8    antagonist, with an     IC   ₅₀      of 67±10 nM and negligible cytotoxicity. The K     _d    value of CU-CPT-8m is determined to be 220 nM. CU-CPT-8m only reduces the proinflammatory response in the TLR8-overexpressing cells strongly supports that CU-CPT-8m directly recognizes TLR8 in cells. It is particularly notable that TLR7 signaling is not affected at concentrations up to 75 μM. TLR7 and TLR8 are closely related and share many common ligands. Treatment of 1 μM CU-CPT-8m completely abolishes the elevation of TNF-α and IL-8 mRNA levels induced by R848. CU-CPT-8m inhibits R848-induced TNF-α production in the differentiated THP-1 monocytes cells in a dose-dependent manner with an IC     ₅₀    of 90±10 nM, which is in good agreement with its IC     ₅₀    value determined in HEK-Blue TLR8 cells.

安全信息

MSDS信息

CPD1578 價格(試劑級)

CPD1578 上下游產(chǎn)品信息