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Melanoma EpiTect Methyl qPCR Array

黑色素瘤甲基化PCR芯片
 

ProductSpeciesTechnologyCat. No.Melanoma EpiTect Methyl qPCR ArrayHumanDNA MethylationEAHS-081ZMelanoma EpiTect Methyl qPCR ArrayMouseDNA MethylationEAMM-081ZMelanoma EpiTect Methyl qPCR ArrayRatDNA MethylationEARN-081Z

The Human Melanoma EpiTect Methyl II Signature PCR Array profiles the promoter methylation status of a panel of 22 genes showing hypo- or hypermethylation in melanoma. Melanoma accounts for less than 5% of skin cancers, but 80% of the deaths, illustrating the aggressiveness and malignancy of the disease. Epigenetic studies of dysregulated and hypermethylated tumor suppressor genes have identified novel therapeutic targets for melanoma. This array includes genes frequently observed by genomewide analyses to be hypermethylated in melanoma, as well as genes involved in melanoma onset and progression. Profiling cellular or fresh tissue genomic DNA samples with these arrays may help correlate CpG island methylation status with biological phenotypes. The results may also help provide further insights into the molecular mechanisms and biological pathways behind oncogenesis and cancer biology. With a simple restriction enzyme digestion and real-time PCR, research studies can analyze the promoter methylation status of 22 different genes involved in melanoma initiation and progression with this DNA methylation PCR array.
The EpiTect Methyl II PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease
 
黑色素瘤甲基化PCR芯片用于研究在黑色素瘤中低甲基化和高甲基化的22個基因的啟動子甲基化狀態(tài)。黑色素瘤占皮膚癌不到5%，但80%的人死亡,說明疾病的侵略性和惡性。表觀遺傳研究低甲基化和高甲基化腫瘤抑制基因鑒定了黑色素瘤新的治療靶標(biāo)。這個芯片上的基因包括全基因組分析發(fā)現(xiàn)在黑色素瘤中經(jīng)常發(fā)生高甲基化的基因，以及參與黑色素瘤發(fā)生和進(jìn)程的基因。利用這些芯片分析細(xì)胞或新鮮組織基因組DNA樣本有助于關(guān)聯(lián)CpG島甲基化狀態(tài)與生物表型。結(jié)果還可以洞察腫瘤發(fā)生和進(jìn)程,及其病理背后的分子機(jī)制和生物學(xué)通路。利用這個芯片，通過簡單的限制性內(nèi)切酶消化和實(shí)時定量PCR，就可以研究分析22個參與黑色素瘤起始和進(jìn)程的不同基因的啟動子甲基化狀態(tài)。
 
提供96-孔板和384-孔板( 4 X 96 )。
Signaling Pathways Dysregulated in Melanoma: GDF15 (PLAB), RB1.
Cellular Stress Responses:
Drug & Chemical Response: CDH3, DNAJC15, LRP2, SOCS3.
Immune: DPP4, IRF8, PRDX2, THBD.
Hypoxia: AKAP12, DPP4, SOCS3.
Oxidative: PRDX2, TPM1.
Cell Growth & Proliferation: AKAP12, DPP4, LRP2, PPP2R4, PRDX2, RB1, SOCS2.
Extracellular Matrix & Cell Adhesion: ADAMTS18, CDH3, DPP4, ENC1, MME, QPCT, SOCS2, SOCS3, TPM1.
Apoptosis Regulation: PRDX2, SOCS2, SOCS3, TNFRSF10A, TP53INP1.
Transcription Factors & Cofactors: IRF8, RB1, TNFRSF10A.
Others: PPP1R3C, RASEF.

黑色素瘤甲基化PCR芯片 Melanoma EpiTect Methyl qPCR Array,黑色素瘤甲基化PCR芯片 Melanoma EpiTect Methyl qPCR Array

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