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產(chǎn)品描述:
Eotaxin also called CCL11 is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-gamma stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and along Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung, and in allergic reactions.

表達(dá)系統(tǒng) :
Escherichia coli

溶解方法:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20°C. Further dilutions should be made in appropriate buffered solutions.

產(chǎn)品組成:
Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.

存儲條件:
This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.

分子量:
Approximately 8.4 kDa, a single non-glycosylated polypeptide chain containing 74 amino acids.

內(nèi)毒素:
Less than 1 EU/μg of Eotaxin/CCL11 as determined by LAL method.

產(chǎn)品用途:
This material is offered by Cyagen Biosciences for research, laboratory or further evaluation purposes. FOR RESEARCH USE ONLY. NOT INTENDED FOR ANY ANIMAL OR HUMAN THERAP EUTIC OR DIAGNOSTIC USE.

生物學(xué)活性:
The biologically active determined by a chemotaxis bioassay using murine CCR3 transfected murine BaF3 cells is in a concentration range of 1.0-10.0 ng/mL.

產(chǎn)品形態(tài):
Sterile filtered white lyophilized (freeze-dried) powder.

氨基酸序列:
HPGSIPTSCC FIMTSKKIPN TLLKSYKRIT NNRCTLKAIV FKTRLGKEIC ADPKKKWVQD ATKHLDQKLQ TPKP

產(chǎn)品純度:
> 96% by SDS-PAGE and HPLC analyses.