產(chǎn)品編號:

300-10T

別名:

OSM

描述:

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis.  Produced by activated T cells, monocytes and Kaposi鈥檚 sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation.  It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi鈥檚 sarcoma cells, but inhibits the growth of some normal and tumor cell lines.  It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells.  OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF.  Human OSM is active on murine cells.  The human OSM gene encodes for a 252 amino acid polypeptide, containing 25 amino acid signal sequence for secretion and a 227 precursor protein.  Proteolytic processing of this precursor removes an 18 amino acid C-terminal peptide, and generates the mature OSM form.  Recombinant Human Oncostatin M is a 23.6 kDa protein, containing 209 amino acid residues.

氨基酸序列:

AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LDPYIRIQGL DVPKLREHCR ERPGAFPSEE TLRGLGRRGF LQTLNATLGC VLHRLADLEQ RLPKAQDLER SGLNIEDLEK LQMARPNILG LRNNIYCMAQ LLDNSDTAEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GRVFSKWGES PNRSRRHSPH QALRKGVRR

來源:

E.coli

純度:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

生物活性:

The ED₅₀as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is 鈮?2.0 ng/ml, corresponding to a specific activity of 鈮?5 x 10⁵ units/mg.

交叉反應:

Mouse, Human

原產(chǎn)國:

USA