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Human/Mouse Nurr1/NGFI-B beta/NR4A2 Affinity Purified PAb 25 UG

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Human/Mouse Nurr1/NGFI-B beta/NR4A2 Affinity Purified PAb 25 UG信息二維碼

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產(chǎn)品介紹

    基本參數(shù)

    詳細說明

    • Species Reactivity

      Human, Mouse

    • Specificity

      Detects human and mouse Nurr1/NGFI?B beta /NR4A2 in direct ELISAs and Western blots.

    • Source

      Polyclonal Goat IgG

    • Purification

      Antigen Affinity-purified

    • Immunogen

      E. coli-derived recombinant mouse Nurr1/NGFI?B beta /NR4A2    
      Val332-Lys558    
      Accession # Q06219

    • Formulation

      Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS.

    • Label

      Unconjugated

    Applications

    • Recommended    
      Concentration

      Sample

    • Western Blot

      0.1 μg/mL

      Recombinant Mouse Nurr1/NGFI?B beta /NR4A2


    • Immunohistochemistry

      5-15 μg/mL

      Immersion fixed differentiated dopamenergic nuerons from D3 mouse embryonic stem cells


    Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

    Preparation and Storage

    • Reconstitution

      Reconstitute at 0.2 mg/mL in sterile PBS.

    • Shipping

      The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

    • Stability & Storage

      Use a manual defrost freezer and avoid repeated freeze-thaw cycles.    

      • 12 months from date of receipt, -20 to -70 °C as supplied.

      • 1 month, 2 to 8 °C under sterile conditions after reconstitution.

      • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

    Background: Nurr1/NGFI-B beta/NR4A2

    Nurr1 belongs to the nerve growth factor-induced clone B subfamily of nuclear receptor superfamily and is designated NR4A2 in the Unified Nomenclature System for NRs. Nurr1 can function as a ligand-independent transcription factor. Nurr1 also heterodimerizes with retinoid X receptors (RXRs) to function as ligand-regulated transcription factor. Nurr1 is important for specification of dopaminergic neurons that degenerate in Parkinson’s disease. Human and mouse Nurr1 share 99% amino acid sequence homology.

    • Long Name:

      Nur-related Factor 1/Nerve Growth Factor Induced B beta/Nuclear Receptor Subfamily 4, Group A, 2

    • Entrez Gene IDs:

      4929 (Human); 18227 (Mouse)

    • Alternate Names:

      human homolog of; NGFI-B beta; NOT; NR4A2; nuclear receptor subfamily 4, group A, member 2; Nurr1; orphan nuclear receptor NR4A2; Orphan nuclear receptor NURR1; T-cell nuclear receptor NOT; TINUR; transcriptionally inducible nuclear receptor related 1; Transcriptionally-inducible nuclear receptor



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