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Recombinant Human WISP-1/CCN4 Protein, CF 50 UG

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Recombinant Human WISP-1/CCN4 Protein, CF 50 UG信息二維碼

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產(chǎn)品介紹

    基本參數(shù)

    詳細說明

    • Purity

      >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie? Blue Staining.

    • Endotoxin Level

      <1.0 EU per 1 μg of the protein by the LAL method.  

    • Activity

      Measured in a cell proliferation assay using NRK?49F rat fibroblasts. Xu, L.     et al. (2000) Gene and Dev.     14:585. The ED    50 for this effect is 1.5-7.5 μg/mL.

    • Source

      Mouse myeloma cell line, NS0-derived Thr23-Asn367, with a 10-His tag

    • Accession #

    • N-terminal Sequence    
      Analysis

      Thr23

    • Predicted Molecular Mass

      39.3 kDa

    • SDS-PAGE

      62 kDa, reducing conditions

    1627-WS

     

    Formulation Lyophilized from a 0.2 μm filtered solution in PBS.


    Reconstitution Reconstitute at 100 μg/mL in sterile PBS.



    Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.


    Stability & Storage:       Use a manual defrost freezer and avoid repeated freeze-thaw cycles.      

    • 12 months from date of receipt, -20 to -70 °C as supplied.

    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.

    • 3 months, -20 to -70 °C under sterile conditions after reconstitution.


    Background: WISP-1/CCN4

    Human WISP-1 (Wnt-induced secreted protein-1; also CNN4) is a 40 kDa, secreted, heparin-binding glycoprotein that is a member of the CCN (or CTGF/Cyr61/Nov) cysteine-rich protein family (1-5).  It is synthesized as a 367 aa precursor that contains a series of structural homology modules.  Following a 22 amino acid (aa) signal sequence, there is a 68 aa IGFBP-like domain (aa 53-120), a 57 aa von Willebrand factor type C (VWC) module (aa 126-182), a 40 aa TSP type I domain (aa 220-259) and a 75 aa, C-terminal cysteine knot motif (aa 273-347).  The VWC module is associated with protein-protein interaction, the TSP domain binds sulfated glycoconjugates, and the cysteine knot mediates dimerization and receptor binding (4).  It is likely that WISP-1 normally circulates as an 80 kDa homodimer (2).  At least five alternative splice forms are known for WISP-1.  One is 30 kDa in size, 258 aa in length, and shows a substitution of a His for aa 95-182.  This removes the VWC domain (2, 6).  A second isoform is 155 aa in length and shows a frameshift at Arg 117 with a unique 38 aa C-terminal extension.  A third is 195 aa in length and shows a 31 aa substitution for the first 203 aa of the full length precursor (6).  This retains the VWC and cysteine knot domains.  A fourth shows a 43 aa substitution for aa 117-367 for a total length of 163 aa.  This effectively removes everything but the IGFBP-like domain (7).  The last splice form contains a deletion of aa 25-269 for a total length of 122 aa.  Thus, only the signal sequence and cysteine knot motifs are retained (8).  This leaves only the IGFBP-like domain (9).  Full-length mature human WISP-1 is 85% aa identical to both mouse and rat WISP-1.  WISP-1 is expressed by osteoblasts and may contribute to fracture healing by promoting bone cell formation (10, 11). 

    • References:

      1. Pennica, D. et al. (1998) Proc. Natl. Acad. Sci. USA 95:14717.

      2. Tanada, S. et al. (2001) Oncogene 20:5525.

      3. Brigstock, D.R. et al. (2003) J. Clin. Pathol. Mol. Pathol. 56:127.

      4. Desnoyers, L. (2004) Curr. Pharm. Des. 10:3913.

      5. Brigstock, D.R. (2003) J. Endocrinol. 178:169.

      6. Li, Z. (2005) GenBank Accession # AAP43925.

      7. Li, Z. (2005) GenBank Accession # AAP43926.

      8. Li, Z. (2005) GenBank Accession # AAP43924.

      9. Cervello, M. et al. (2004) Ann. N.Y. Acad. Sci. 1028:432.

      10. French, D.M. et al. (2004), Am. J. Pathol. 165:855.

      11. Parisi, M.S. et al. (2006) Bone 38:671.

    • Long Name:

      Wnt-1 Induced Secreted Protein 1

    • Entrez Gene IDs:

      8840 (Human); 22402 (Mouse)

    • Alternate Names:

      CCN family member 4; CCN4; CCN4WISP1tc; WISP1; WISP-1; WISP1c; WISP1i; WNT1 induced secreted protein 1; WNT1 inducible signaling pathway protein 1; Wnt-1 inducible signaling pathway protein 1; wnt-1 signaling pathway protein 1; Wnt-1-induced secreted protein; WNT1-inducible-signaling pathway protein 1






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