• Species Reactivity

  Mouse

• Specificity

  Detects mouse ChemR23 in flow cytometry.

• Source

  Monoclonal Rat IgG    _2B Clone # 477806

• Purification

  Protein A or G purified from hybridoma culture supernatant

• Immunogen

  NS0 mouse myeloma cell line transfected with mouse ChemR23

• Formulation

  Supplied in a saline solution containing BSA and Sodium Azide.

• Label

  Alexa Fluor 488

Applications

• 
  

  Recommended    
  Concentration

  Sample

• Flow Cytometry

  5 μL/10    ⁶ cells

  See below

• 
  

Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

Data Examples

Preparation and Storage

• Shipping

  The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

• Stability & Storage

  Protect from light.    Do not freeze.    

• 12 months from date of receipt, 2 to 8 °C as supplied.

Background: ChemR23

ChemR23 is a chemoattractant receptor expressed on dendritic cells and inflammatory M1 macrophages. ChemR23 binds Chemerin and Resolvin E1 (a lipid mediator), and promotes inflammation resolution. ChemR23 also functions as a coreceptor for SIV and some primary HIV-1 strains (1,2). Mouse and human ChemR23 share 80% amino acid sequence identity.

• References:

1. Samson, M. et al. (1998) Eur. J. Immunol. 28:1689.

2. Herova, M. et al. (2015) J. Immunol. 194:2330.

• Long Name:

  Chemokine-like Receptor 1/Orphan G Protein-coupled Receptor ChemR23

• Entrez Gene IDs:

  1240 (Human); 14747 (Mouse); 60669 (Rat)

• Alternate Names:

  CHEMERINR; chemokine receptor-like 1; chemokine-like receptor 1; ChemR23; cmklr1; Dez; Gpcr27; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ; MGC126105; MGC126106; orphan G-protein coupled receptor, Dez