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Human IL-23 p19 Alexa Fluor 488 MAb (Clone 727753) 100 TESTS

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Human IL-23 p19 Alexa Fluor 488 MAb (Clone 727753) 100 TESTS信息二維碼

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產(chǎn)品介紹

    基本參數(shù)

    詳細(xì)說明

    • Species Reactivity

      Human

    • Specificity

      Detects human IL-23 p19 in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant human (rh) IL-23 heterodimer is observed, less than 10% cross-reactivity with recombinant mouse (rm) IL-23 heterodimer is observed, and no cross-reactivity with recombinant feline IL-23 p19, recombinant canine (rca) IL-23 p19, and recombinant rat IL-23 p19 is observed.. In Western blots, no cross-reactivity with rcaIL-23 p19 or rmIL-23 p19 is observed.

    • Source

      Monoclonal Mouse IgG    2B Clone # 727753

    • Purification

      Protein A or G purified from hybridoma culture supernatant

    • Immunogen

      E. coli-derived recombinant human IL-23 p19    
      Arg20-Pro189    
      Accession # Q9NPF7

    • Formulation

      Supplied in a saline solution containing BSA and Sodium Azide.

    • Label

      Alexa Fluor 488

    Applications


    • Recommended    
      Concentration

      Sample

    • Intracellular Staining by Flow Cytometry

      5 μL/10    6 cells

      See below


    Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

    Data Examples

    Intracellular Staining by Flow Cytometry      
         

    Detection of IL?23 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) either (A) treated with LPS or (B) untreated, were stained with Mouse Anti-Human CD14 APC?conjugated Monoclonal Antibody (Catalog # ) and Mouse Anti-Human IL?23 p19 Alexa Fluor? 488?conjugated Monoclonal Antibody (Catalog # IC17161G). Quadrant markers were set based on isotype control (Catalog # ). To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (Catalog # ) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # ). View our protocol for .

    Preparation and Storage

    • Shipping

      The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

    • Stability & Storage

      Protect from light.    Do not freeze.    

      • 12 months from date of receipt, 2 to 8 °C as supplied.

    Background: IL-23

    Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 (1?5). The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Human and mouse p19 share 70% aa sequence identity. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R). IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both na?ve and memory human T cells, the effects of IL-23 is restricted to memory T cells. In mouse, IL-23 but not IL-12, has also been shown to induce memory T cells to secret IL-17, a potent proinflammatory cytokine. IL-12 and IL-23 can induce IL-12 production from mouse splenic DC of both the CD8  - and CD8  + subtypes, however only IL-23 can act directly on CD8  + DC to mediate immunogenic presentation of poorly immunogenic tumor/self peptide.

    • References:

      1. Oppmann, B. et al. (2000) Immunity 13:715.

      2. Lankford, C.S. and D.M. Frucht (2003) J. Leukoc. Biol. 73:49.

      3. Parham, C. et al. (2002) J. Immunol. 168:5699.

      4. Belladonna, M.L. et al. (2002) J. Immunol. 168:5448.

      5. Aggarwal, S. et al. (2003) J. Biol. Chem. 278:1910.

    • Long Name:

      Interleukin 23

    • Entrez Gene IDs:

      51561 (Human); 83430 (Mouse)

    • Alternate Names:

      IL23; IL-23; IL23A; IL-23A; IL-23-A; IL-23p19; IL23P19P19; interleukin 23 p19 subunit; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; Interleukin-23 subunit p19; JKA3 induced upon T-cell activation; MGC79388; SGRF; SGRFIL-23 subunit alpha












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