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Mouse IL-23 R Allophycocyanin MAb (Clone 753317) 100 TESTS

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Mouse IL-23 R Allophycocyanin MAb (Clone 753317) 100 TESTS信息二維碼

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產品介紹

    基本參數(shù)

    詳細說明

    • Species Reactivity

      Mouse

    • Specificity

      Detects endogenous mouse IL-23 R by flow cytometry.

    • Source

      Monoclonal Rat IgG    1 Clone # 753317

    • Purification

      Protein A or G purified from hybridoma culture supernatant

    • Immunogen

      Mouse myeloma cell line NS0-derived recombinant mouse IL-23 R    
      Gly24-Asp372    
      Accession # Q8K4B4

    • Formulation

      Supplied in a saline solution containing BSA and Sodium Azide.

    • Label

      Allophycocyanin

    Applications


    • Recommended    
      Concentration

      Sample

    • Flow Cytometry

      10 μL/10    6 cells

      See below


    Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

    Data Examples

    Flow Cytometry      
         

    Detection of IL?23 R in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes treated with 10 μg/mL Anti-CD3 (Catalog # ), 5 μg/mL Anti-CD28 (Catalog # ), 10 ng/mL Recombinant Mouse TGF-beta 1 (Catalog # ), 20 ng/mL Recombinant Mouse IL-23 (Catalog # ), 40 ng/mL Recombinant Mouse IL-6 (Catalog # ), and 10 ng/mL Recombinant Mouse IL-1 beta (Catalog # ) for 5 days to induce T17 activation were stained with Rat Anti-Mouse CD4 PE?conjugated Monoclonal Antibody (Catalog # FAB554P) and either (A) Rat Anti-Mouse IL?23 R APC?conjugated Monoclonal Antibody (Catalog # FAB16861A) or (B) Rat IgG1 Allophycocyanin Isotype Control (Catalog # ). View our protocol for . 

    Flow Cytometry      
         

    Detection of IL?23 R in HEK293 Human Cell Line Transfected with Mouse IL-23 R by Flow Cytometry.

    HEK293 human embryonic kidney cell line transfected with (A) mouse IL-23 R or (B) irrelevant transfectants was stained with Rat Anti-Mouse IL?23 R APC?conjugated Monoclonal Antibody (Catalog # FAB16861A, filled histogram) or isotype control antibody (Catalog # , open histogram). View our protocol for .

    Preparation and Storage

    • Shipping

      The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

    • Stability & Storage

      Protect from light.    Do not freeze.    

      • 12 months from date of receipt, 2 to 8 °C as supplied.

    Background: IL-23 R

    Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 (1?5). The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R) (3). Mouse IL-23 R cDNA encodes a 644 amino acid (aa) type I transmembrane protein with a 23 aa residue signal peptide, a 349 aa residue extracellular domain, a 23 aa residue transmembrane domain and a 249 aa residue cytoplasmic region. IL-23 R shares structural features with the IL-12 R beta 2, including an N-terminal Ig-like domain, two cytokine receptor domains and multiple glycosylation sites in the extracellular domain. IL-23 R lacks the three extracellular membrane-proximal fibronectin-type III domains present on IL-12 R beta 2. IL-23 R has a WQPWS sequence in the transmembrane-proximal cytokine receptor domain similar to the cytokine receptor signature WSXWS motif. The cytoplasmic region of IL-23 R has three potential Src homology 2 domain-binding sites and two potential Stat-binding sites. The gene for human IL-23 R is located on human chromosome 1 within 150 kb of IL-12 R beta 2. Human and mouse IL-23 R share 66% amino acid sequence identity. Mouse IL-23 R is expressed in mouse Th1 and Th2 cells, bone marrow, dendritic cells and macrophages. It is also expressed by mouse CD4  + CD45RB  low memory T cells but at much lower levels by mouse CD4  + CD45RB  high cells. IL-23 initiates a signal transduction cascade similar to that of IL-12 and involves Jak2, Tyk2, STAT1, STAT3, STAT4, and STAT5. IL-23 has biological activities that are similar to, but distinct from, IL-12.

    • References:

      1. Oppmann, B. et al. (2000) Immunity 13:715.

      2. Lankford, C.S. and D.M. Frucht (2003) J. Leukoc. Biol. 73:49.

      3. Parham, C. et al. (2002) J. Immunol. 168:5448.

      4. Belladonna, M.L. et al. (2002) J. Immunol. 168:5448.

      5. Aggarwal, S. et al. (2003) J. Biol. Chem. 278:1910.

    • Long Name:

      Interleukin 23 Receptor

    • Entrez Gene IDs:

      149233 (Human); 209590 (Mouse)

    • Alternate Names:

      IBD17; IL-23 R; IL-23 receptor; IL23R; IL-23R; interleukin 23 receptor; interleukin-23 receptor












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