性做久久久久久久免费看,无码精品人妻一区二区三区湄公河 ,熟妇的奶头又大又长奶水视频,无码国产精品一区二区免费式芒果,亚瑟av亚洲精品一区二区

Recombinant Mouse Thrombospondin-4 Protein, CF 50 UG

所屬行業(yè):儀器設備 ????有0人感興趣

Recombinant Mouse Thrombospondin-4 Protein, CF 50 UG信息二維碼

微信掃碼

?
基礎投資電議
推薦指數(shù)?
  • 區(qū)域全國
  • 留言暫無
  • 瀏覽0
  • 更新2024-11-24 19:01
  • 到期長期有效






更多>我還有產(chǎn)品
Recombinant Mouse Integrin alpha 2 beta 1 Protein, CF  50 UG Recombinant Mouse Integrin alpha 9 beta 1 Protein, CF  50 UG Recombinant Mouse Integrin alpha L beta 2 Protein, CF  50 UG Recombinant Mouse Neuroplastin Protein, CF  50 UG Recombinant Mouse Integrin alpha 6 beta 1 Protein, CF  50 UG Recombinant Mouse Integrin alpha 11 beta 1 Protein, CF  50 UG

產(chǎn)品介紹

    基本參數(shù)

    詳細說明

    • Purity

      >90%, by SDS-PAGE under reducing conditions and visualized by silver stain

    • Endotoxin Level

      <0.10 EU per 1 μg of the protein by the LAL method.  

    • Activity

      Measured by the ability of the immobilized protein to support the adhesion of SVEC4?10 mouse vascular endothelial cells. The ED    50 for this effect is 0.1-0.5 μg/mL.

    • Source

      Chinese Hamster Ovary cell line, CHO-derived Gln27-Asn963, with a C-terminal 6-His tag

    • Accession #

    • N-terminal Sequence    
      Analysis

      Gln27 predicted: No results obtained, sequencing might be blocked

    • Predicted Molecular Mass

      104.4 kDa

    • SDS-PAGE

      120-145 kDa, reducing conditions

    7860-TH

     

    Formulation Lyophilized from a 0.2 μm filtered solution in PBS.


    Reconstitution Reconstitute at 200 μg/mL in PBS.



    Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.


    Stability & Storage:       Use a manual defrost freezer and avoid repeated freeze-thaw cycles.      

    • 12 months from date of receipt, -20 to -70 °C as supplied.

    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.

    • 3 months, -20 to -70 °C under sterile conditions after reconstitution.


    Background: Thrombospondin-4

    Thrombospondin-4 (TSP-4) is an approximately 140 kDa matricellular protein that is secreted as a disulfide-linked pentamer. Within the Thrombospondin family, TSP?3 and TSP?5/COMP are also pentameric, while TSP?1 and TSP?2 are trimeric. TSP?4 regulates cell?cell and cell matrix interactions and plays a role in cardiovascular physiology and neuronal development (1, 2). Mature mouse TSP?4 consists of an N?terminal heparin-binding domain, a coiled coil motif, four EGF?like repeats, seven TSP type?3 repeats (one with an RGD motif), and a TSP C?terminal domain (2, 3). Mouse TSP?4 shares 93% and 97% amino acid sequence identity with human and rat TSP?4, respectively. TSP?4 binds a variety of matrix proteins including Collagens I, II, III, V, Laminin?1, Fibronectin, and Matrilin?2 (4). Interactions of TSP?4 with non?collagenous proteins are independent of divalent cations, whereas interactions with collagenous proteins are enhanced in the presence of zinc (4). TSP?4 binds to cell surface Integrins containing the alpha M, beta 2, or beta 3 chains (5, 6). It is expressed in skeletal muscle and tendon as well as by vascular smooth muscle and endothelial cells (7?9). It is up?regulated in cardiomyocytes during pressure overload and is required for mediating the responsive increase in cardiac contractility (10). In humans, a polymorphism of TSP-4 (A387P) is associated with myocardial infarction (11). TSP-4 contributes to the development of inflammation and atherosclerosis by promoting macrophage and neutrophil adhesion to the vasculature (5, 6). In the nervous system, TSP?4 is expressed by astrocytes and neurons and is enriched at neuromuscular junctions and synapse?rich layers of the brain and retina (9, 12, 13). It promotes neuronal adhesion, neurite outgrowth, and excitatory synaptogenesis (9, 13, 14). TSP?4 is up?regulated in the spinal cord following peripheral nerve injury where it contributes to presynaptic hypersensitivity and hyperalgesia (12). It is also up?regulated in muscle following denervation (9). TSP?4 is additionally secreted by tumor?associated fibroblasts in gastric adenocarcinoma, particularly in regions of tumor cell invasion (15).

    • References:

      1. Murphy-Ullrich, J.E. and R.V. Iozzo (2012) Matrix Biol. 31:152.

      2. Lawler, J. et al. (1995) J. Biol. Chem. 270:2809.

      3. Newton, G. et al. (1999) Mamm. Genome 10:1010.

      4. Narouz-Ott, L. et al. (2000) J. Biol. Chem. 275:37110.

      5. Pluskota, E. et al. (2005) Blood 106:3970.

      6. Frolova, E.G. et al. (2010) Circ. Res. 107:1313.

      7. Sodersten, F. et al. (2007) Connect. Tiss. Res. 48:254.

      8. Stenina, O.I. et al. (2003) Circulation 108:1514.

      9. Arber, S. and P. Caroni (1995) J. Cell Biol. 131:1083.

      10. Cingolani, O.H. et al. (2011) Circ. Res. 109:1410.

      11. Stenina, O.I. et al. (2007) Arterioscler. Thromb. Vasc. Biol. 27:1886.

      12. Kim, D.-S. et al. (2012) J. Neurosci. 32:8977.

      13. Dunkle, E.T. et al. (2007) Exp. Eye Res. 84:707.

      14. Eroglu, C. et al. (2009) Cell 139:380.

      15. Forster, S. et al. (2011) Mod. Pathol. 24:1390.

    • Entrez Gene IDs:

      7060 (Human); 21828 (Mouse)

    • Alternate Names:

      THBS4; thrombospondin 4; Thrombospondin4; Thrombospondin-4; TSP4; TSP-4




    舉報收藏 0評論 0
?
熱門項目排行榜快速發(fā)布信息
14-(2-碘代乙基)辛基苯 9
2高溫波導測試
3格列美脲 98%+?RG? 5g
4N,N-Diethyl-cyclohexan
54-溴-3,5-二氯三氟甲苯
6Recombinant Human LILR
儀器設備排行榜快速發(fā)布信息
1Milliplex Catalog ID.H
2Recombinant Mouse IL-1
35ml Protein A40 Plus親
4STBCi014-A 1 VIAL
5WNT2基因敲除HEK293T細
61ml Q70強陰離子交換預
最新加入項目快速發(fā)布信息
1TWS用膠
2電感膠
3電子膠
4環(huán)氧AB膠
5導電銀膠(晶振)
6固晶膠

猜你喜歡產(chǎn)品快速發(fā)布信息

相關(guān)欄目

還沒找到您需要的儀器設備產(chǎn)品?立即發(fā)布您的求購意向,讓儀器設備公司主動與您聯(lián)系!

立即發(fā)布項目意向

免責聲明

本網(wǎng)頁所展示的有關(guān)【Recombinant Mouse Thrombospondin-4 Protein, CF 50 UG_儀器設備_云試劑自營四店】的信息/圖片/參數(shù)等由云試劑的會員【云試劑自營四店】提供,由云試劑會員【云試劑自營四店】自行對信息/圖片/參數(shù)等的真實性、準確性和合法性負責,本平臺(本網(wǎng)站)僅提供展示服務,請謹慎交易,因交易而產(chǎn)生的法律關(guān)系及法律糾紛由您自行協(xié)商解決,本平臺(本網(wǎng)站)對此不承擔任何責任。您在本網(wǎng)頁可以瀏覽【Recombinant Mouse Thrombospondin-4 Protein, CF 50 UG_儀器設備_云試劑自營四店】有關(guān)的信息/圖片/價格等及提供【Recombinant Mouse Thrombospondin-4 Protein, CF 50 UG_儀器設備_云試劑自營四店】的商家公司簡介、聯(lián)系方式等信息。

聯(lián)系方式

在您的合法權(quán)益受到侵害時,歡迎您向郵箱發(fā)送郵件,或者進入《網(wǎng)站意見反饋》了解投訴處理流程,我們將竭誠為您服務,感謝您對云試劑的關(guān)注與支持!

按排行字母分類找加盟項目:

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z