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Equine IL-1 beta/IL-1F2 MAb (Clone 608714) 25 UG

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Equine IL-1 beta/IL-1F2 MAb (Clone 608714) 25 UG信息二維碼

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產(chǎn)品介紹

    基本參數(shù)

    詳細(xì)說明

    • Species Reactivity

      Equine

    • Specificity

      Detects equine IL-1 beta /IL-1F2 in direct ELISAs. In direct ELISAs, 100% cross?reactivity with recombinant canine, guinea pig, mouse, rat, and porcine IL?1 beta is observed and 10?50% cross?reactivity with recombinant feline, human, rabbit, and rhesus IL?1 beta is observed. Approximately 20% cross?reactivity with recombinant mouse (rm) IL?36 alpha and no cross?reactivity with recombinant human (rh) IL?36 alpha, rhIL?36 gamma, rhIL?1F10, rhIL?36Ra, rmIL?1Ra, rmIL?18, or rmIL?36 beta is observed.

    • Source

      Monoclonal Mouse IgG    1 Clone # 608714

    • Purification

      Protein A or G purified from hybridoma culture supernatant

    • Immunogen

      E. coli-derived recombinant equine IL-1 beta /IL-1F2    
      Ala116-Ala268    
      Accession # Q28286

    • Formulation

      Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS.

    • Label

      Unconjugated

    Applications

    • Recommended    
      Concentration

      Sample

    • Immunocytochemistry

      20-30 μg/mL

      See below


    Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

    Data Examples

    Immunocytochemistry      
         

    IL?1 beta /IL?1F2 in Equine PBMCs. IL?1 beta /IL?1F2 was detected in immersion fixed equine peripheral blood mononuclear cells (PBMCs) using Mouse Anti-Equine IL?1 beta /IL?1F2 Monoclonal Antibody (Catalog # MAB33401) at 25 μg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights? 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # ) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for .

    Preparation and Storage

    • Reconstitution

      Sterile PBS to a final concentration of 0.5 mg/mL.

    • Shipping

      The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

    • Stability & Storage

      Use a manual defrost freezer and avoid repeated freeze-thaw cycles.    

      • 12 months from date of receipt, -20 to -70 °C as supplied.

      • 1 month, 2 to 8 °C under sterile conditions after reconstitution.

      • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

    Background: IL-1 beta/IL-1F2

    IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2), which are the products of distinct genes. IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 27% amino acid (aa) identity in equine. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI (1-4). The equine IL-1 beta cDNA encodes a 268 aa precursor. A 115 aa propeptide is cleaved intracellularly by the cysteine protease IL-1 beta -converting enzyme (Caspase-1/ICE) to generate the active cytokine (5-7). An alternatively spliced form of equine IL-1 beta has a deletion which encompasses the Caspase-1 cleavage site and potentially results in a membrane-associated form (8). The 17 kDa mature equine IL-1 beta shares 65%-75% aa sequence identity with canine, cotton rat, feline, human, mouse, porcine, rat, and rhesus IL-1 beta.

    • References:

      1. Allan, S.M. et al. (2005) Nat. Rev. Immunol. 5:629.

      2. Boraschi, D. and A. Tagliabue (2006) Vitam. Horm. 74:229.

      3. Kornman, K.S. (2006) Am. J. Clin. Nutr. 83:475S.

      4. Isoda, K. and F. Ohsuzu (2006) J. Atheroscler. Thromb. 13:21.

      5. Kato, H. et al. (1997) Vet. Immunol. Immunopathol. 48:221.

      6. Howard, R.D. et al. (1998) Am. J. Vet. Res. 59:704.

      7. Martinon, F. and J. Tschopp (2007) Cell Death Differ. 14:10.

      8. Kato, H. et al. (1996) Gene 177:11.

    • Long Name:

      Interleukin 1 beta

    • Entrez Gene IDs:

      3553 (Human); 16176 (Mouse); 24494 (Rat); 397122 (Porcine); 403974 (Canine); 100034237 (Equine); 100135556 (Guinea Pig)

    • Alternate Names:

      catabolin; IL1 beta; IL-1 beta; IL-1; IL1B; IL-1b; IL1-BETA; IL-1F2; IL1F2IL-1 beta; interleukin 1, beta; interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta





















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