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Recombinant Human Nogo-A (aa 566-748) Fc Chimera Protein, CF 50 UG

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Recombinant Human Nogo-A (aa 566-748) Fc Chimera Protein, CF 50 UG信息二維碼

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產品介紹

    基本參數(shù)

    詳細說明

    • Purity

      >80%, by SDS-PAGE under reducing conditions and visualized by silver stain

    • Endotoxin Level

      <0.10 EU per 1 μg of the protein by the LAL method.  

    • Activity

      Measured by its ability to inhibit neurite outgrowth of dissociated E13 chick embryonic dorsal root ganglia (DRG) neurons. Able to significantly inhibit neurite outgrowth when immobilized as a 3 μL droplet containing 200 ng on a nitrocellulose-coated microplate.

    • Source

      Chinese Hamster Ovary cell line, CHO-derived

      Human Nogo-A
      (Val566 - Phe748) &
      (Thr569 - Phe748)
      Accession # Q9NQC3
      IEGRMDHuman IgG1
      (Pro100 - Lys330)
      N-terminus
      C-terminus
    • Accession #

    • N-terminal Sequence    
      Analysis

      Val566 & Thr569

    • Structure / Form

      Disulfide-linked homodimer

    • Predicted Molecular Mass

      46 kDa (monomer)

    • SDS-PAGE

      70-90 kDa, reducing conditions

    3515-NG

     

    Formulation Lyophilized from a 0.2 μm filtered solution in PBS.


    Reconstitution Reconstitute at 100 μg/mL in sterile PBS.



    Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.


    Stability & Storage:       Use a manual defrost freezer and avoid repeated freeze-thaw cycles.      

    • 12 months from date of receipt, -20 to -70 °C as supplied.

    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.

    • 3 months, -20 to -70 °C under sterile conditions after reconstitution.


    Background: Nogo-A

    Human Nogo-A (also reticulon-4) is a member of the reticulon family of transmembrane proteins. This family is characterized by the presence of a nonsignal sequence-containing N-terminus, a topologically conserved 200 amino acid (aa) C-terminus that contains two transmembrane domains with an ER-retention motif, and a punctate intracellular distribution within the ER that is reminescent of a reticulum (1 - 4). In human, Nogo exists in five isoforms (5 - 7). The full length human form (Nogo-A) is 1192 aa in length and contains a 1018 aa N-terminus, a 21 aa transmembrane segment, a 94 aa connecting “l(fā)oop”, a second 21 aa transmembrane segment, and a 38 aa C-terminus. Three areas are of particular interest. One is a stretch of 66 aa within the 94 aa connecting loop. This segment is reported to bind to the GPI-linked Nogo receptor/p75 complex on axons and induce growth cone collapse (8 - 10). Two other areas in the N-terminus have also been discovered to have bioactivity (8, 11, 12). Based on rat, aa 57 - 184 in human (aa 59 - 172 in rat) should block fibroblast spreading, while aa 566 - 748 in human (aa 544 - 725 in rat) block neurite outgrowth and block fibroblast spreading (8, 12, 13). The exact topology of Nogo-A is unclear. The N- and C-termini may be extracellular with the “l(fā)oop” region intracellular, or the situation could be reversed (13 - 15). Alternatively, the loop region and N-terminus may be on the same side of the membrane (3, 8). The four additional isoforms are shorter than Nogo-A (199 aa [Nogo-C], 373 aa [Nogo-B], 392 aa and 986 aa, respectively) (7). Although highly divergent, all contain the same C-terminal stretch, aa 1005 - 1192. Both Nogo-B and C are reported to complex with Nogo-A (16). Notably, Nogo-A is expressed in neurons, endothelial cells. oligodendrocytes, fibroblasts and myoblasts (12, 16 - 18). Human Nogo-A is 78% aa identical to mouse and rat Nogo-A overall, with 98% aa identity in the loop region and approximately 80% aa identity in the aa 566 - 748 segment.

    • References:

      1. Oertle, T. et al. (2003) FASEB J. 17:1238.

      2. GrandPre, T. et al. (2000) Nature 403:439.

      3. Yan, R. et al. (2006) Cell. Mol. Life Sci. 63:877.

      4. Teng, F.Y.H. et al. (2004) J. Neurochem. 89:801.

      5. Chen, M.S. et al. (2000) Nature 403:434.

      6. Morris, N.J. et al. (1999) Biochim. Biophys. Acta 1450:68.

      7. GenBank Accession # Q9NQC3.

      8. Oertle, T. et al. (2003) J. Neurosci. 23:5393.

      9. Fournier, A.E. et al. (2001) Nature 409:341.

      10. Wang, K.C. et al. (2002) Nature 420:74.

      11. Prinjha, R. et al. (2000) Nature 403:384.

      12. Dodd, D.A. et al. (2005) J. Biol. Chem. 280:12494.

      13. Li, M. et al. (2004) Eur. J. Biochem. 271:3512.

      14. Huber, A.B. and M.E. Schwab (2000) Biol. Chem. 381:407.

      15. Ng, C.E.L. and B.L. Tang (2002) J. Neurosci. Res. 67:559.

      16. Dodd, D.A. et al. (2005) J. Biol. Chem. 280:12494.

      17. Wang, X. et al. (2002) J. Neurosci. 22:5505.

      18. Acevedo, L. et al. (2004) Nat. Med. 10:382.

    • Long Name:

      Reticulon 4A

    • Entrez Gene IDs:

      57142 (Human); 68585 (Mouse); 83765 (Rat)

    • Alternate Names:

      NI220; NogoA; Nogo-A; RTN4; RTN4A




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