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Recombinant Mouse IL-15 R alpha Fc Chimera Protein, CF 100 UG

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產(chǎn)品介紹

    基本參數(shù)

    詳細說明

    • Purity

      >90%, by SDS-PAGE under reducing conditions and visualized by silver stain

    • Endotoxin Level

      <0.10 EU per 1 μg of the protein by the LAL method.  

    • Activity

      Measured by its ability to block human IL-15-induced proliferation of CTLL?2 mouse cytotoxic T cells. Ruchatz, H.     et al. (1998) J. Immunol.     160:5654. The ED    50 for this effect is 0.1-0.5 ng/mL in the presence of 0.1 ng/mL recombinant human IL-15.

    • Source

      Mouse myeloma cell line, NS0-derived

      Mouse IL-15 R alpha
      (Gly33 - Lys205)
      Accession # Q60819
      IEGRMDHuman IgG1
      (Pro100 - Lys330)
      N-terminus
      C-terminus

      Contains a small amount (10%) of free IL-15 R alpha and Fc generated by proteolytic cleavage.

    • Accession #

    • N-terminal Sequence    
      Analysis

      Gly33

    • Structure / Form

      Disulfide-linked homodimer

    • Predicted Molecular Mass

      44.9 kDa (monomer)

    • SDS-PAGE

      80-90 kDa, 42 kDa and 35 kDa, reducing conditions

    551-MR

     

    Formulation Lyophilized from a 0.2 μm filtered solution in PBS.


    Reconstitution Reconstitute at 100 μg/mL in sterile PBS.



    Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.


    Stability & Storage:       Use a manual defrost freezer and avoid repeated freeze-thaw cycles.      

    • 12 months from date of receipt, -20 to -70 °C as supplied.

    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.

    • 3 months, -20 to -70 °C under sterile conditions after reconstitution.


    Background: IL-15 R alpha

    Interleukin 15 Receptor alpha (IL 15 R alpha ), also known as CD215, is a widely expressed 60 kDa transmembrane glycoprotein that plays an important role in the homeostasis and activation of NK cells and CD8+ memory T cells and participates in the development and function of many other hematopoietic cell types and non?immune cell types (1 ? 3). Mature mouse IL?15 R alpha consists of a 173 aa extracellular domain (ECD) containing one N?linked glycosylation site, a 21 aa transmembrane segment, and a 37 aa cytoplasmic tail (4). Within the ECD, mouse IL?15 R alpha shares 59% and 89% aa sequence identity with human and rat IL?15 R alpha, respectively. Alternate splicing of mouse IL?15 R alpha generates additional isoforms with an N?terminal truncation or variable length deletions in the ECD. IL?15 R alpha binds to Interleukin?15 with high affinity (4). IL?15 additionally interacts with lower affinity to a complex of IL?2 R beta and the common gamma chain ( gamma c) which are also subunits of the IL?2 receptor complex (5, 6). The use of shared receptor components contributes to the overlapping biological effects of IL?15 and IL?2. The dominant mechanism of IL?15 action is known as transpresentation in which IL?15/IL?15 R alpha complexes are expressed on the surface of one cell and interact with complexes of IL?2 R beta / gamma c on adjacent cells (7). This enables cells to respond to IL?15 even if they do not express IL?15 R alpha (8 ? 10). IL?15/IL?15 R alpha complexes can transmit reverse signaling that promotes cellular adhesion, tyrosine phosphorylation of intracellular proteins, and cytokine secretion by the IL?15/IL?15 R alpha expressing cells (11, 12). Shed soluble forms of IL?15 R alpha retain the ability to bind tightly to IL?15 and can inhibit IL?15 bioactivity (4, 13, 14).

    • References:

      1. Ma, A. et al. (2006) Annu. Rev. Immunol. 24:657.

      2. Di Sabatino, A. et al. (2011) Cytokine Growth Factor Rev. 22:19.

      3. Budagian, V. et al. (2006) Cytokine Growth Factor Rev. 17:259.

      4. Giri, J.G. et al. (1995) EMBO 14:3654.

      5. Grabstein, K. et al. (1994) Science 264:965.

      6. Giri, J. et al. (1994) EMBO J. 13:2822.

      7. Stonier, S.W. and K.S. Schluns (2010) Immunol. Lett. 127:85.

      8. Duitman, E.H. et al. (2008) Mol. Cell. Biol. 28:4851.

      9. Dubois, S. et al. (2002) Immunity 17:537.

      10. Burkett, P.R. et al. (2004) J. Exp. Med. 200:825.

      11. Budagian, V. et al. (2004) J. Biol. Chem. 279:42192.

      12. Neely, G.G. et al. (2004) J. Immunol. 172:4225.

      13. Budagian, V. et al. (2004) J. Biol. Chem. 279:40368.

      14. Mortier, E. et al. (2004) J. Immunol. 173:1681.

    • Long Name:

      Interleukin 15 Receptor alpha

    • Entrez Gene IDs:

      3601 (Human); 16169 (Mouse)

    • Alternate Names:

      CD215 antigen; CD215; IL-15 R alpha; IL-15 receptor subunit alpha; IL15R alpha; IL15RA; IL-15Ra; IL-15R-alpha; interleukin 15 receptor, alpha; interleukin-15 receptor subunit alpha; MGC104179







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